P糖蛋白在胃癌中的表达及预后关系

Study of P-glycoprotein expression in stomach carcinoma and its relationship with prognosis

目的 为了探讨P糖蛋白 (P glycoprotein ,P gp)在不同分型 ,分期胃癌中的表达及 /与预后的关系。 方法 应用抗鼠抗人P gp单克隆抗体JSB1对 80例胃癌进行免疫组化研究。 结果 显示P gp表达与临床分期有关 (P <0 .0 5 ) ,Ⅰ期表达率 5 3 .5 % ,Ⅱ期表达率 63 .1% ,Ⅲ期 66.6% ,呈正相关。与胃癌组织分化程度无关 (P >0 .0 5 )。不同生存年段的P gp表达率无差异 (P >0 .0 5 ) ,但P gp在癌旁正常组织中的阳性表达率与生存期有显著性差异 (P <0 .0 5 )。 结论 提示P gp表达与胃癌的分期相关 ,与分型和预后无关 。

Objective To investigate the patterns of P glycoprotein expression and its influences on prognosis.Methods 80 cases of paraffin embedded stomach cancer tissue were stained immunohistochemically for P glycoprotein using JSBI monclonal antibody after heated under high pressure and correlations among the results and tumor type,clinical stage and prognosis were studied.Results P glycoprotein expressed in 66.5% cancer tissues and the expression was associated with tumor clinical stage (P<0.05).There was no relationship between tumor defferentiation and prognosis (P>0.05).But its expression in normal tissue was positively significant with survial time.Conclusions Expression of P grlycoprotein is related to the biologic behaviors of stomach cancer.Immunohistochemical assessment of P rlycoprotein expression in stomach carcinoma/in normal tissure might be useful for choosing chemotherapeutic drugs and predicting prognosis. [