直肠癌根治术后介入导管动脉化疗对肝转移的预防作用

The preventive effect on hepatic metastasis from rectal cancer after redical resection by intraarterial regional chemotherapy

目的 探讨介入导管动脉化疗对直肠癌根治术后患者肝转移的作用。方法 治疗组 5 6例直肠癌常规根治术后患者 ,以介入导管动脉化疗替代全身静脉化疗 ,靶血管为肝固有动脉、肠系膜上动脉、双侧髂内动脉 ;对照组 44例 ,采用常规静脉化疗 ;两组化疗方案均为 5 Fu +DDP +MMC ,治疗后观察其 5年的肝转移发生率及存活率。结果 治疗组 5年内出现肝转移 8例 ( 1 4.3% )。死亡 1 6例 ,5年存活率 71 .4% ;对照组肝转移 9例 ( 2 0 .5 % ) ,死亡 1 7例 ,5年存活率 6 1 .4% ,两组的肝转移发生率和 5年存活率均有显著差异 (P <0 .0 1 )。结论 直肠癌常规根治术后患者以介入导管动脉化疗替代全身静脉化疗可明显降低肿瘤肝转移的发生率 ,提高其

Objective To evaluate the effect of catheterization of intraarterial chemoterapy on hepatic metastasis from rectal carcinoma after redical resection.Methods Fifty six patients undergoing radical resection for their rectal carcinoma were given intraarterial regional chemotherapy consisting of 5 Fu,MMC and DDP.The rate of hepatic metastasis and 5 year survival rate were observed.Results The rate of hepatic metastasis from rectal carcinoma was 14.3% and 5 year survival rate was 71.4% respectively,while the rate of hepatic metastasis and survival rate for the control group were 20.4% and 61.4%.Conclusions The intraarterial chemotherapy can reduce the rate of hepatic metastasis from rectal carcinoma after redical resection and increase the 5 year survival rate. [