参脉注射液联合去乙酰毛花苷丙注射液治疗急性左心衰竭的疗效分析

Therapeutic effect evaluation on the treatment on acute left heart failure with Shenmai injection and deslanoside

目的：观察参脉注射液辅助西医常规疗法治疗急性左心力衰竭的临床疗效。方法采用随机数字表法按1∶1的比例将132例患者随机分为两组各66例，对照组采用西地兰、卡托普利、利尿剂及氨茶碱等治疗。治疗组在对照组治疗基础上静滴参脉注射液，1次/d，两组均治疗1个月后观察患者左室射血分数（LVEF）、左窒舒张末内径（LVEDD）值、B型利钠肽（BNP）指标变化，及两组患者的24 h动态心电图。结果两组患者LVEF值与BNP浓度治疗后[治疗组分别为（40.42±4.32）%、（306.57±201.21）pg/ml，对照组分别为（37.92±3.32）%、（451.51±294.23）pg/ml]均较同组治疗前明显改善[治疗组分别为（35.28±4.15）%、（540.17±382.23）pg/ml，对照组分别为（35.13±2.35）%、（572.35±422.21）pg/ml]，且治疗组疗效优于对照组（P＜0.05）。两组LVEDD、24 h平均心率治疗后[治疗组分别为（59.81±8.38）mm、（79.62±6.38）次/min，对照组分别为（60.91±7.31）mm、（82.61±6.32）次/min]均较同组治疗前[治疗组分别为（60.87±7.75）mm、（85.03±7.75）次/min，对照组分别为（61.81±7.35）mm、（86.23±8.35）次/min]有所改善，但差异无统计学意义（P＞0.05）。结论参脉注射液对急性左心力衰竭有良好的治疗作用。

Objective To observe the effect of treating acute left heart failure with Shenmai injection and auxiliary conventional western medicine. Methods 132 patients were randomly divided into a control group and a treatment group, with 66 cases in each group. The control group was treated with lanatoside C, captopril, diuretics, and aminophylline. While the treatment group was additionally treated with Shenmai injection on the basis of the control group. Left ventricular ejection fraction（LVEF）, left smothering end-diastolic diameter（LVEDD）value, the index of b-type natriuretic peptide（BNP）, and 24 h dynamic electrocardiogram（ecg）were observed in both groups after 1 month’s treatment. Results LVEF and BNP were improved in both groups after the treatment[LVEF and BNP were（40.42 ± 4.32）%, （306.57 ± 201.21）pg/ml in the treatment group and（37.92±3.32）%, （451.51±294.23）pg/ml in the control group before the treatment;（35.28±4.15）%, （540.17±382.23）pg/ml in the treatment group and（35.13±2.35）%, （572.35± 422.21）pg/ml in the control group after the treatment], and the curative effect in the treatment group was better than the control group（P＆lt;0.05）. LVEDD and 24 h average heart rate were also improved in both groups after the treatment [LVEDD and 24 h average heart rate were（59.81±59.81）mm, （79.62±6.38）times/min in the treatment group and（60.91±7.31）mm, （82.61±6.32）times/min in the control group before the treatment;（60.87 ± 7.75）mm, （85.03 ± 7.75）times/min in the treatment group and（61.81 ± 7.35）mm,（86.23 ± 8.35）times/min in the control group after the treatment], but there was no statistical differenc（P＆gt;0.05）. Conclusion Shenmai injection has good effects in the treatment of acute left heart failure.