富血性肿瘤平阳霉素碘油乳剂栓塞后的病理学研究

The Pathological Study on Hypervascular Tumor by Pingyangmycin lipiodol Emulsion Arterial Embolization

目的 :探讨富血管性肿瘤平阳霉素碘油乳剂 (PLE)靶动脉栓塞后病理学特点及意义。材料与方法 :对 12例PLE栓塞后肿瘤手术标本多部位取材 ,观察瘤体病理变化。结果 :12例标本肿瘤血管血栓形成 4例 ,增生狭窄 3例。管壁坏死残留轮廓 5例。瘤组织均发生凝固性坏死 ,位于中心 4例 ,边缘 1例 ,中心及边缘均有 7例。坏死率 10 0 %者 1例 ,75 %～ 99% 8例 ,5 0 %～ 74%者 1例 ,2 5 %～ 49%者 2例。肿瘤周边坏死假包膜形成 4例。结论 :PLE具有祛血管作用 ,可用于富血管肿瘤经动脉栓塞治疗。

Purpose: To investigate the pathological features and its significance of hypervascular tumor after intra arterial embolization with pingyangmycin lipiodol emulsion (PLE). Materials and methods: After PLE embolization, resected tumor specimens were cut into slice in multi regions and observed in 12 patients. Results: The pathological manifestations consisted of thrombus (n=4), stenosis of tumor vessel (n=3) and necrosis of vascular wall with the residual outline (n=5). Coagulation necrosis of the tumor tissue was found in all the specimens. The necrotic regions of the tumor located in center (n=4), edge (n=1) or both of then (n=7). Necrotic rate (NR) was 100% in 1 case, 75%～99% in 8 cases, 50%～74% in 1 case, 25%～49% in 2 cases. Pseudocapsules were found on the boundary of the tumor specimens in 4 cases. Conclusion: PLE has the devascular effect, it can be used for intra arterial embolization of hypervascular tumor.