沉默信息调节因子l的肾脏保护作用研究进展

Research progress on renal protective effects of Sirt1

沉默信息调控因子2样蛋白(Sirtuins)是一类在所有生命体内广泛存在的序列保守的蛋白质家族,可介导卡路里限制相关的健康获益机制,在包括哺乳动物在内的多种生物体中显现出延缓衰老和延长寿命的功效。其中,哺乳动物的沉默信息调节因子1(Sirt1)是被研究最广泛的家族成员,它具有烟酰胺腺嘌呤二核苷酸(NAD+)依赖的去乙酰化酶活性,参与细胞能量代谢、氧化还原等多条信号通路的转导和组织对代谢、缺氧、氧化应激等刺激的调控。肾脏中,Sirt1参与正常生理调节,具有保护细胞作用。本文对Sirt1的生物学功能和在肾脏疾病中的研究进展进行了综述,并讨论了其作为改善肾脏病临床转归的治疗靶点的潜力。

The silent information regulator two-like proteins （Sirtuins）are a conserved family of proteins found in all domains of life,which underlie the beneficial effects of caloric restriction in most classes of organism including mammals,showing the effectiveness of delaying aging and prolonging life span. Mammalian silent information regulator 1 （Sirt1 ）,the most extensively studied family member,possesses nicotinamide adenine dinucleotide （NAD＋）-dependent deacetylase activity,being involved in transduction of many signaling pathways such as cellular energy metabolism and redox,and in regulation of metabolism, hypoxia,and oxidative stress.Sirt1 participates in the regulation of renal physiology,and is cytoprotective in the kidney.This paper has reviewed research progress about the biological functions of Sirt1 as well as its role in renal diseases,and its potential as a therapy target of renal diseases to improve clinical outcomes was also discussed.