肿瘤标记物CA_(125)、CA_(153)、CA_(199)与CEA在肺癌诊断中的意义

TUMOR MARKER CA_(125) 、 CA_(153) 、 CA_(199) AND CEA IN LUNG CANCER

目的 :研究四种肿瘤标记物CA12 5、CA153 、CA199与CEA在肺癌诊断中的意义 ,并以常见的几种呼吸道炎症性疾病 (RIDs)作为对照。结果 :肺癌患者CA12 5、CA153 、CA199及CEA水平均显著高于RIDs患者 (P <0 .0 0 1) ,而CA12 5、CA153 、CA199及CEA水平在肺癌的三种组织学类型和各期肺癌中并显著性差异 (P >0 .0 5 )。采有四项指标的平均值作为标准 ,虽然并不能显著提高诊断的灵敏度 (P >0 .0 5 ) ,但可显著提高诊断的特异性 (P <0 .0 5或 0 .0 1)。结论 :CA12 5、CA153 、CA199及CEA可作为肺癌的标记物 。

Four tumor markers,CA 125 ,CA 153 ,CA 199 and CEA are studied for their relations with lung cancer,using Respiratory Inflammatory Diseases,RIDs (bronchitis,bronchiectasis and pneumonia)as control.The result shows that the serum levels of CA 125 ,CA 153 ,CA 199 and CEA are significantly higher in the patients with lung cancer than in those with RIDs(P<0.001).There are not significant differences of the serum level of CA 125 ,CA 153 ,CA 199 and in different tissular types of lung cancer and at different phases of lung cancer (P>0.05).The mean value of the four markers is used for a new standard for judging lung cancer.The sensitivity is not significantly higher,but the specificity is significantly lifted(P<0.05 or 0.01).It seems that CA 125 ,CA 153 ,CA 199 and CEA can be useful markers for lung cancer,and that the detection of the four markers can play assistant role in the judgement of lung cancer.