两种方法复制的大鼠脾虚模型的病理研究

Comparatve Pathological Study on Two Types of Spleen-asthenia Model Rats Induced by Different Methods

同一证候的患者由不同病因引起者,或同一证候的模型由不同造型方法形成者,都可能会有不同的病理及疗效反应.过去的研究对此重视不足。本实验在大鼠脾虚型(醋酸性)胃溃疡模型上对两种不同的脾虚造型方法(Ⅰ、耗气破气加饥饱失常法;Ⅱ、利血平法)进行比较观察,并比较二者对同样药物(泰胃美)的治疗反应。结果两种模型在外观、体重、溃疡指数、粘连指数、病理组织学观察方面均未见明显差别,泰胃美对二者的疗效也基本一致。可能机制是两种模型的主要病理均是全身和局部的严重营养不良导致胃粘膜易损性增高、修复能力下降,从而显示同样的造模及治疗结果。本实验是研究“同证异理同治”的一个初步尝试。

There may be different pathological reactions and therapeutic effects among the cases or pathological models with the same clinical manifestations but induced by different causes. Yet this has not been fully realized in the previous studies. Tha present test uses two ways to establish spleen-asthenia rat medels by inducing gastric ulcer with gi-exhausting method combined with hunger, and by injection of reserpine. Furthermore a comparison of response to the therapy of Tagamet beween two models was made. The results show that between the two groups there are no obvious difference in symptoms, weights, indexes of ulcer, indexes of adhesion and changes of histopathology, and Tagamet has the same therapeutic effect on the two models. This suggests that the two models have the same pathological change of serious malnutrition which leads to vulnerability and poor repairing function of gastric mucosa. This test is a tentative attempt at the study of 'different treatment for the same zheng'.