115例脑卒中患者血清神经元特异性烯醇化酶测定及其意义

Serum Levels of Neuron specific Enolase and Its Significance in 115 Cases of Patients with Stroke

目的 研究脑卒中时血清神经元特异性烯醇化酶 (NSE)的变化及与神经功能缺损的关系。方法 脑出血46例 ,脑梗死 6 9例 ,正常对照 2 1例。患者分别在起病 3d内及 2周时采集血标本。血清NSE测定采用酶联免疫分析方法 ,神经功能缺损评定按斯堪的纳维亚卒中量表 (SSS)标准进行。结果 脑梗死、脑出血组 3d内及起病 2周时血清NSE明显高于正常对照组 (均为P <0 .0 0 1) ,并与SSS呈明显正相关 (P <0 .0 0 1)。结论 脑卒中早期血清NSE明显升高 ,血清NSE与SSS之间有明显相关性。

Objective To investigate serum levels of neuron specific enolase (NSE) and its clinical significance in the patients with cerebral haemorrhage and infarction, and confirm the correlation between the physical disabilities and serum levels of neuron specific enolase.Methods Forty six cases with cerebral haemorrhage , sixty nine caces with cerebral infarctions and twenty one healthy control caces were included.Blood samples of the patients were taken at 3rd day and 14th day after the event of stroke respectively.Serum levels of NSE were detected with ELISA. Physical disabilities were evaluated with Scandinavian Stroke Scale(SSS).Results NES serum levels at 3rd day in the patients with stroke are significantly higher than that of controls(P<0.001) and on 14th day in the same group of patients(P<0.001). A significant positive relationship between NSE serum levels on 3rd day and the SSS value of physical disabilities were observed.Conclusions NES serum levels are increased in the early stage of stroke and there is a positive relationship between NSE serum level and SSS value of physical disabilities.