摘要
目的 :探讨抗心磷脂抗体 (ACA)在冠心病 (CHD)发病中的意义及其与血脂的关系。方法 :5 2例 CHD患者及44名健康体检者分别用 EL ISA和免疫透射比浊法测定血清 ACA- Ig G,ACA- Ig M,ACA- Ig A和 TC,TG,HDL,Apo A- I,Apo B的含量。结果 :冠心病组的 ACA- Ig G水平明显高于正常对照 (P<0 .0 1) ,而 ACA- Ig G变化的水平与 TG,HDL,Apo A- I改变呈显著的相关关系 (r分别为 0 .31,- 0 .2 7和 - 0 .2 9,均 P<0 .0 1)。结论 :血清 ACA-Ig G可与血脂代谢紊乱可能共同形成 CHD的发病机制或有促进血脂代谢紊乱的作用。
AIM:To study the role of anticardiolipin antibody (ACA) in coronary heart disease(CHD) and the relationship of blood lipid in CHD patients . METHODS: Serum ACA IgG, IgM,IgA and TC,TG,HDL,ApoA I,ApoB were measured by ELISA and immune turbidity assay in 52 CHD patients and in 44 healthy people. RESULTS: The levels of ACA IgG of the CHD group were markely higher than those of the control group( P <0.01) and changes in ACA IgG levels of were closely associated with TG,HDL,ApoA I ( r =0.31, P <0.01, 99% CI 0.05~0.53; r = -0.27, P <0.01, 99% CI -0.01～-0.49; r =-0.29, P <0.01, 99% CI -0.03～-0.51). CONCLUSION: The high level serum ACA IgG autoantibody may play a role mediated pathogenesis of CHD.
出处
《心脏杂志》
CAS
2001年第1期50-51,共2页
Chinese Heart Journal
关键词
冠状动脉疾病
抗心磷脂抗体
血脂
coronary disease
anticardiolipin antibody
blood lipid
