摘要
目的探讨杜仲多糖对兔心肌缺血再灌注损伤的保护作用。方法将兔随机分为4组(每组8只),即假手术组、缺血再灌注组、丹参片预处理组、杜仲多糖预处理组。监测各组兔血清心肌酶谱、超氧化物歧化酶(SOD)、丙二醛(MDA)等水平的变化。结果杜仲多糖预处理组心肌酶、SOD、MDA含量与缺血再灌注组、丹参预处理组比较差异显著(P<0.05)。结论杜仲多糖对兔心肌缺血再灌注损伤能够产生较好的保护作用。
Objective To demonstrate the effect of Eucommia ulmoides polysaccharides （EUP） on rabbit myocardial ischemia- reperfusion injury model. Methods Rabbits were divided into four groups including Sham group, ischemia-reperfusion group, groups pretreated with Salvia miltiorrhiza and EUP. And the indexes of CK, CK-MB, LDH, AST, SOD, and MDA were detected. Results Results showed that those indexes in group pretreated with EUP differed significantly from other groups （P 〈 0.05）. Conclusion It shows that EUP may decrease the injury of myocardial ischemia-reperfusion so as to get the better protection of rabbits.
出处
《药物评价研究》
CAS
2014年第1期34-36,共3页
Drug Evaluation Research
关键词
心肌缺血
缺血再灌注损伤
杜仲多糖
杜仲
myocardial ischemia
ischemia-reperfusion injury
Eucommia ulmoides polysaccharides
Eucommia ulmoides Oliv.
