中药药动学研究评价模式的发展

Development of evaluation mode for pharmacokinetic of Chinese materia medica

中药是一个复杂的巨系统,其药效是其中多种化学成分相互作用所产生的综合效果。中药药动学研究经历了从"单成分、单靶点"到"多成分、多靶点"的转变,相应的药动学评价模式也经历了相似的发展过程,从最初针对单体成分的药动学研究,到以单成分研究单味中药及复方的药动学,再到多组分整合药动学,以及之后的以药动学–药效学结合模式评价复方药动学。对以上中药药动学评价模式的发展进行了初步探讨。

Chinese materia medica （CMM） is a complicated macrosystem, and the efficacy is synthetic by variety of chemical composition. The pharmacokinetic study of CMM transformed from ＂single component, single targets＂ to ＂multiple components, multiple targets＂, and its evaluation mode transformed in a similar process： pharmacokinetic study aimed at monomer composition, pharmacokinetic study of single Chinese herb or compound prescription through single component, integrated pharmacokinetics of multi component, and uses of pharmacokinetics/pharmacodynamics binding mode to evaluate the pharmacokinetics of CMM, and this development process was discussed primarily in this article.