血管生成生长因子治疗缺血性心脏病

Therapeutic Use of Angiogenesis Growth Factors in Ischemic Heart Disease

冠状动脉侧支循环可为缺血心肌供血。血管生成生长因子可诱导血管生成 ,促进侧支循环建立。血管内皮生长因子、成纤维细胞生长因子已被动物试验、临床试验证明可诱导缺血区侧支循环建立、缓解心绞痛、改善心功能 ,为缺血性心脏病的治疗提供了新的方法。

The coronary collateral circulation is an alternative source of blood supply to the myocardium jeopardized by failure of the original vessel to provide adequate flow. Angiogenesis growth factors induce angiogenesis to promote collateral circulation, been demonstrated in a number of different animal test and phase Ⅰ clinical experience to induce collateralization in the ischemic area and improve cardiac function. Although there are several unsolved questions, the pharmacologic use of angiogenesis growth factors will represent a viable therapeutic alternative for the patients with ischemic heart disease.