肺表面活性物质疗效影响因素分析

ANALYSIS EFFECTIVE FACTORS OF CURATIVE EFFECT IN PULMONARY SURFACTANT THERAPY

为研究肺表面活性物质 (PS)治疗疗效影响的因素。分成功组和失败组总结分析 1 996年 6月～ 1 998年 6月使用进口肺表面活性物质治疗和预防 2 1例新生儿肺透明膜病的情况。结果 使用 PS前两组 p H、PCO2 有显著性差异 ,PO2 无显著性差异 ;出生体重、PS使用剂量有显著性差异 ,而孕周、Apgar评分、用药时年龄无显著性差异 ;并发症中肺出血、颅内出血、酸中毒有显著性差异。结果显示 早期足量应用 PS,注意纠酸、积极治疗合并症。

To Study the effective factors of pulmonary surfactant (PS) in therapy. Methods: 21 infants with hyaline membrane disease (HMI) from June 1 996-June 1 998 were diveded to therapy successfully group and failed group who were used import PS for treatment or prevention. Results: There were remarkable difference in pH and PCO 2 of two groups before using PS. No notable difference in PO 2. There were rcmarkable difference in born weight, and does of PS. But no difference in gestation weeks, Appgar score and age. About the complications, pulmonary hemorrhage, intracranial hemorrhage and acidosis have significanl difference. Conclusions: PS should be used in early stage and enough does. At the same time, ti's important to sorrect acidosis and treat complications actively.