新生儿缺氧缺血性脑病与NO、NOS、PRL水平的相关性研究

A RESEARCH OF MUTUALITY OF NEWBORN INFANTS HIE AND THE LEVEL OF NO, NOS, PRL

本文采用放射免疫法和比色法测定 6 8例 HIE及 30例正常新生儿血浆NO、NOS及血清 PRL 活性水平 ,探讨一氧化氮 (NO)、一氧化氮合成酶 (NOS)及催乳素 (PRL)在新生儿缺氧缺血性脑病 (HIE)的病机、病情进展、预后中的作用及临床意义。结果显示 :HIE急性期 NO、NOS、PRL水平较正常新生儿明显升高 (P<0 .0 5 ) ,中度和重度 HIE三项指标升高更显著 (P均 <0 .0 1 ) ,且 HIE惊厥组急性期血清PRL 水平显著高于非惊厥组 (P<0 .0 1 ) ,且与惊厥发作持续时间呈正相关 (r=0 .485 ,P<0 .0 1 )。提示 :NO、NOS、PRL水平高低与 HIE患儿脑损伤严重程度有关 ,可作为判断病情。

To take RIA and colorimetry measured the active level of NO, NOS in the plasm and PRL in the serum on 68 cases of HIE and 30 cases of normal newborn infants. To discuss the function and clinic significance of NO, NOS and PRL on pathogenesis, progress of the state of illness and prognosis of newborn infants HIE. Results In the HIE acute period, the lvevel of NO, NOS, PRL is significantly higher than normal infants (P<0.05). The indexes of the three items of moderate of serious HIE are higher than acute period (P<0.01). The level of PRL in the serum and the HIE convulsion acute period is significantly higher than that of the non-convulsion (P<0.01), and it appears positive relationship with the continuous time of convulsion taking place (r=0.485,P<0.01). Meanwhile, The level of NO, NOS and PRL is associate with the degree that HIE sick children get impairment of brain. It can be taken as an index to judge the state of illness, prognosis and whether the convulsion will break out or not.