C反应蛋白对晚期结直肠癌FOLFOX4方案化疗后生存期的预测意义

Effects of C-reactive protein on the survival phase of patients with advanced colorectal cancer undergoing FOLFOX4 chemotherapy

目的 探讨C反应蛋白（CRP）对晚期结直肠癌患者应用FOLFOX4化疗方案后生存期的预测价值.方法 分析61例晚期结直肠癌患者FOLFOX4方案（LV/5-FU＋L-OHP）化疗前后的临床资料,应用Cox比例风险模型确定影响无进展生存时间的独立预后因素,并进一步通过Kaplan-Meier生存曲线观测化疗前CRP水平与生存期的关系.结果 化疗前CRP水平、肿瘤转移、姑息性切除以及PS评分与化疗后患者的生存期有关,化疗前CRP水平是预测晚期结直肠癌患者化疗后生存期的独立因素.结论 化疗前检测CRP浓度对于预测晚期结直肠癌患者预后有重要的临床意义.

Abstract： Objective To investigate the effects of C reactive protein （CRP） on the survival phase of patients with advanced colorectal cancer undergoing FOLFOX4 chemotherapy. Methods Clinical data from sixty one patients with advanced colorectal cancer before and after receiving FOLFOX4 （ LV/5 FU ＋ L OHP） chemotherapy were collected. Then, the Cox proportional hazard regression model was adopted to determine independent prognostic factors for progress free survival, while the Kaplan Mare survival curves with Log rank analysis was used to evaluate the relationship be tween the level of CRP before chemotherapy and the duration of survival. Results Our results indicated that the level of CRP before chemotherapy, tumor metastasis, palliative resection and PS scores were associated with for the duration of sur vival of patients after chemotherapy. The level of CRP prior to chemotherapy was an independent factor to predict the dura tion of post chemotherapy survival of patients with advanced colorectal cancer. Conclusion The level of CRP prior to chemotherapy is of importance to predict the prognosis of patients with advanced CRC undergoing FOLFOX4 chemotherapy.