河南省脑性瘫痪儿童危险因素分析

Analysis of the risk factors in children with cerebral palsy in Henan province

【摘要】目的探讨河南省儿童脑性瘫痪（脑瘫）发生的危险因素。方法采用分层整群随机抽样法对河南省0～6岁儿童进行脑瘫的流行病学调查和以人群为基础的1：4匹配病例对照研究，采用Epidata3．2建立数据库，用SAS9．1．3软件进行单因素和多因素条件Logistic回归分析。结果实际调查河南省0～6岁儿童51108例，确诊脑瘫患儿120例。有9项因素纳入多因素回归方程，其中母亲怀孕时年龄≥30岁、孕期入住新装修的居室、孕期患病、孕前月经紊乱、孕次≥3、不良孕产史、早产（孕周〈37周）、新生儿期患病均为发生脑瘫的危险因素；人均年收入〉1万元是保护性因素。结论导致脑瘫发生的因素是多方面的，主要与母孕期患病、母亲不良孕产史、早产、新生儿期患病、家庭收入等密切相关。积极开展孕期健康指导，高危儿出生后早期筛查及干预治疗，可以达到优生优育的目的。

Objective To explore the risk factors in children with cerebral palsy （CP） in Henan provi- nce. Methods All resident children （0 -6 years old）were extracted as the research subjects by stratified cluster ran- dom sampling principle, and made epidemiological investigation and according to 1 - 4 case-control research of CP cases based on population sampling ,from Sep. 2011 to Sep. 2012 in Henan province. The database were established by Epida- ta 3.2, and analyzed by SAS 9. 1.3 software for univariate and multivariate statistical analysis. Results The total num- ber of children aged 0 -6 years was 51 108 in actual investigation, and the number of children with CP was 120. There were 9 factors included in the regression equation, and statistical analysis could be performed. The risk factors were ranked as mother＇s age at pregnancy/〉 30, pregnancy in the newly renovated house, pregnancy times I〉 3, having a histo- ry of abnormal pregnancy, premature birth and the neonatal disease were risk factors;the annual per-capita income 〉 10 000 was a protective factor. Conclusions The incidence of CP may contribute to a variety of factors, but it is mainly due to pregnancy diseases, abnormal pregnancy, premature birth, neonatal disease, and low family income, etc. Health instructions during pregnancy, earlier screening and intervention of higher risk of CP can help to realize the goal of bearing and rearing better children.