血尿酸水平与冠心病慢性心功能不全的相关性

Correlation between serum uric acid and chronic cardiac insufficiency of patients with coronary heart disease

目的探讨血尿酸水平和冠心病慢性心功能不全的关系。方法将296例冠心病患者分为两组:心功能正常组173例,心功能不全组123例,心功能不全组按纽约心脏病学会NYHA分级分为心功能Ⅱ级组(n=31),心功能Ⅲ级组(n=40),心功能Ⅳ级组(n=52)。应用尿酸氧化酶法测定血尿酸浓度。结果①心功能正常组血尿酸浓度(330.62±89.21)μmol/L,高尿酸血症发生率21.97%;心功能不全组血尿酸浓度(415.63±100.30)μmol/L,高尿酸血症发生率50.41%(P<0.01)。②心功能Ⅱ级亚组血尿酸浓度(362.37±101.01)μmol/L,高尿酸血症发生率25.81%;心功能Ⅲ级亚组血尿酸浓度(389.12±100.37)μmol/L,高尿酸血症发生率35.00%;心功能Ⅳ级亚组血尿酸浓度(427.21±98.33)μmol/L,高尿酸血症发生率82.69%;各组间血尿酸水平差异有统计学意义(P<0.05)。结论冠心病慢性心功能不全患者血尿酸水平升高,血尿酸水平与心功能不全的严重程度呈正相关。

Objective To investigate the relationship between serum uric acid and chronic cardiac insuffi-ciency of patients with coronary heart diseases.Methods Patients with coronary heart diseases were divided into 2 groups：normal cardiac function group（173cases）and cardiac dysfunction group（123cases）.According to the New York Heart Association（NYHA）criteria,a total of 173 cardiac dysfunction patients were divided into Group NYHAⅡ（n=31）,Group NYHAⅢ（n=40）,Group NYHAⅣ（n=52）,The level of SUA was measured with urate oxidase method.Results （1）The mean SUA level in normal cardiac function group was（330.62±89.21）μmol/L,and the total incidence of hyperuricemia（HUA）was 21.97%.The mean SUA level in cardiac dysfunction group was （415.63 ±100.30）μmol/L,and the total incidence of HUA was 50.41%.（2）The mean SUA level in patients with NYHAⅡ,NYHA Ⅲ,NYHA Ⅳwas （362.37±101.01）μmol/L,（389.12 ±00.37）μmol/L,and （427.21 ±98.33）μmol/L respectively,and the incidences of HUA were 25.81%,35.00%,and 82.69%respectively.There was signif-icant difference in SUA among these groups（P〈0.05 ）.Conclusion The mean SUA level in patients with cardiac dysfunction is higher than patients with normal cardiac function.There is a positive correlation between the level of SUA and the severity of cardiac dysfunction.