34例孟鲁司特与布地奈德联合治疗小儿哮喘的疗效分析

34 cases of meng LuSi and budesonide combined curative effect analysis for the treatment of infantile asthma

目的探讨对哮喘小儿采用布地奈德联合孟鲁司特治疗的效果。方法抽取98例2011年6月日—2012年6月日之间在我院接受哮喘治疗小儿的病历资料,并采用回顾性的方法分析,其中34例患儿采用的是布地奈德联合孟鲁司特治疗的方法,28例采用的是单一孟鲁司特药物治疗的方法,36例采用的是单一布地奈德药物治疗的方法,分别将其命名为治疗组、对照A组和对照B组,3组患儿持续性治疗3个月之后,对所有患儿进行随访,观察和对比3组患儿的治疗成效、复发率以及不良反应情况。结果以上三组患儿在接受治疗之后,患者的各项情况与治疗前相比均得到明显改善,并且治疗组患儿的各项情况要明显的优于对照组(A和B),三组患儿治疗的有效率分别为94.12%(32/34)、67.86%(19/28)、77.78%(28/36),治疗组与对照组之间差异具有统计学意义(P<0.05)。对照A组和对照B组之间仅具有可比性。对照组2例患儿发生了不良反应,进行停药处理后,症状均消失,不具有统计学意义(P>0.05)。三组患儿的复发率情况分别为2.94%(1/34)、10.71%(3/28)、11.11%(4/36),治疗组与对照组之间差异具有统计学意义(P<0.05)。结论在临床治疗过程中,采用布地奈德联合孟鲁司特治疗小儿哮喘具有较好的效果,并且发生药物不良反应的几率也很小,因此,值得将该治疗方法大力推广应用。

Objective To investigate the pediatric asthma with budesonide combined meng LuSi treatment effect. Methods 98 cas- es of 2011.6.1--2012.6.1. Asthma treated in our hospital between pediatric medical records, and adopt the method of retrospective analysis of 34 cases with budesonide is A special treatment of the joint LuSi meng, 28 patients with A single meng LuSi drug treatment methods, 36 cases using A single budesonide therapy method, named respectively in treatment group and control group A and control group B, three groups of children with persistent 3 months after treatment, follow-up of all children observed and compared three groups of children with treatment effect, the recurrence rate and adverse reactions. Results Of the above three groups of children after treatment, the patients in all kinds of situation compared with before treatment were obviously improved, and the treatment group with each situation significantly better than the control group （A and B）, the efficiency of three groups of children with treatment were 94.12% （32/34）, 67.86% （19/28）, 77.78% （28/36）, statistically significant differences between treat- merit group and control group （P〈0.05）. Comparison between group A and control group B only comparable. Control group 2 cases occurred adverse reactions after treatment discontinuation, symptoms disappear, not statistically significant （P〉0.05）. Of three groups of children with the recurrence rate was 2.94% （1/34）, 10.71% （3/28）, 11.11% （4/36）, statistically significant differences be- tween treatment group and control group （P〈0.05）. Conclusion In the process of clinical treatment, the use of budesonide com- bined meng LuSi treatment of infantile asthma has good effect, and the chance of adverse drug reactions are also small, therefore, deserves the treatment promoted application.