阿托伐他汀对大动脉粥样硬化型急性缺血性脑卒中临床观察

Clinical observation of atorvastatin in treatment of large artery atherosclerosis subtype of acute ischemic stroke

目的讨论阿托伐他汀治疗大动脉粥样硬化型急性缺血性脑卒中的临床效果。方法选取大动脉粥样硬化型急性脑梗死患者100例,随机分为观察组及对照组。对照组常规给予抗血小板聚集药、神经营养药、对症处理及早期神经康复;观察组在对照组治疗的基础上给予阿托伐他汀钙片20mg,1次/晚,连续服用14d,治疗前后记录NIHSS评分;并检测治疗前后CRP、TC、LDL-C、Cr与ALT,及各种与治疗相关的不良反应。结果观察组NIHSS评分显著高于对照组(P<0.05),CRP、TC、LDL-C有显著降低(P<0.01),不良反应少,无严重不良反应。结论阿托伐他汀治疗大动脉粥样硬化型急性缺血性脑卒中疗效确切,可显著改善预后,安全性好。

Objective To discuss the clinical efficacy of atorvastatin in the treatment of large artery atherosclerosis subtype of a- cute ischemic stroke. Methods 100 patients with large artery atherosclerosis in patients with acute cerebral infarction were select- ed, and divided randomly into observation group and control group. The control group were given conventional anti platelet aggre- gation drugs, neurotrophic drugs, symptomatic treatment and early rehabilitation of nerve; the observation group was given Ator- vastatin Calcium Tablets 20mg based on the control group treatment, 1 times / late, continuous administration of 14d before and af- ter treatment, NIHSS scores; and measured before and after treatment CRP, TC, LDL-C, Cr and ALT, adverse reactions and treat- ment related. Results Observation group NIHSS score was significantly higher than the control group （P〈0.05）, CRP, TC, LDL-C decreased significantly （P〈0.01）, less adverse reaction, no serious adverse reactions. ConclusiOn Atorvastatin in the treatment of large artery atherosclerosis effect of acute ischemic stroke is exact, can significantly improve the prognosis, good safety.