各型病毒性肝炎患者血清一氧化氮水平的测定及临床意义

DETECTION AND CLINICAL SIGNIFICANCE OF NITRIC OXIDE IN HEPATITIS PATIENTS SERUM

目的 :为了解一氧化氮 (NO)在肝损害中所起的作用 ,采用硝酸还原酶法检测慢性肝炎、重型肝炎、肝硬化患者血清NO水平。慢性肝炎组血清NO值升高 ,与重型肝炎、肝硬化及对照组比较差异有显著性 (P <0 .0 5 ) ,而重型肝炎组、失代偿性肝硬化组、对照组中血清NO值比较差异无显著性 (P >0 .0 5 ) ,PTA <40 %的患者NO值与 >40 %的患者比较差异有显著性 (P <0 .0 5 ) ,低白蛋白血症患者其NO值与正常白蛋白血症患者比较差异有显著性 (P <0 .0 5 )。结果显示在引起肝损害机制中 ,一氧化氮具有双重效应作用。

With understand the role of nitric oxide in the liver damage,serum nitric oxide levels in 20 patients with chronic hepatitis,24 patients with severe hepatitis,9 patients with cirrhosis and 10 healthy controls had been tested.Levels of nitric oxide were statistically higher (P<0.05) in chronic hepatitis than in patients with severe hepatitis,cirrhosis and healthy controls.Then levels of nitric oxide were not statistically significant (P>0.05) in severe hepatitis,cirrhosis and healthy control.Levels of nitric oxide were statistically lower in patients of PTA <40% than patients of PTA>40% (P<0.05).Also levels of nitric oxide were statistically lower in patients of low albumin than patients of normal albumin (P<0.05).The result show that nitric oxide have twoedged role in liver damage mechanism.