依达拉奉联合七叶皂苷钠治疗脑出血的疗效及安全性分析

The clinical effect and safety observation of using edaravone combined with sodium aescinate to treat cerebral hemorrhage

目的探讨依达拉奉联合七叶皂苷钠治疗脑出血的临床疗效并对其安全性进行观察。方法选取2010-12—2012-12我院收治的178例脑出血患者为研究对象,随机分为实验组和对照组各89例。对照组单七叶皂苷钠治疗,实验组采用依达拉奉联合七叶皂苷钠治疗,观察2组治疗后的神经功能和自身恢复情况及脑水肿、出血情况。综合各指标判断依达拉奉联合七叶皂苷钠的临床疗效。结果治疗后实验组神经功能缺损下降速度明显快于对照组,差异具有统计学意义(P<0.05)。实验组总有效率94.38%,高于对照组的76.40%。治疗后2组脑水肿均有所增大,但实验组增大程度明显小于对照组,脑血肿均明显减小,实验组更显著。2组相比差异具有统计学意义(P<0.05)。结论依达拉奉联合七叶皂苷钠治疗脑出血比单用七叶皂苷钠,效果更佳,更值得在临床推广。

Objective To exporle and analyze the clinical effect and safety of using edaravone combined with sodium aesci- nate to treat cerebral hemorrhage. Methods 178 patients with cerebral hemorrhage were chosed at our hospital form December 2010 to December 2012 , all the patients were randomly divided into experimental and control groups, with 89 cases in each group. For the control group using a simple aescine sodium, while the experimental group using edaravone aescine sodium, pa- tients were observed on neurological function, self- recovery, cerebral edema and hemorrhage situation, after treatment, the clinical efficacy of edaravone combined with sodium aescinate was evaluated according to comprehensive indexes. Results after different treatments, neurological deficit scores of the experimental group decreased faster than the control group with statisti- cal significance, the two groups have varying degrees of improvement , the total effective rate of the experimental group （94.38%） was significantly higher than control group （76.40%）. After treatment, the cerebral edema in both groups in- creased, but the extent of the edema in the experimental group was significantly less than which in the control group; the cere- bral hematoma were reduced in both groups , but more significantly in the experimental group. Conclusion Compared with so- dium aescinate treatment only, edaravone combined with sodium aeseinate has Better efficacy and is worth of promotion in clini- cal practice.