经皮经导管射频消融去肾交感神经术治疗难治性高血压临床研究

Clinical study on percutaneous radiofrequency catheter ablation of renal sympathetic surgery for treatment of refractory hypertension

目的探讨经皮经导管射频消融去肾交感神经术对难治性高血压的治疗效果。方法选择我院住院部2011-10—2012-09收治的难治性高血压患者73例,随机分为RDN组和对照组,比较2组临床疗效、手术前后血压控制情况及实验室指标。结果 RDN组总有效率达91.89%,对照组69.44%;随访发现,RDN组术后1周、1个月、3个月、6个月收缩压和舒张压降低,差异有统计学意义(均P<0.05)。对照组治疗后血压有所下降,较RDN组下降缓慢;难治性高血压RDN术后实验室各指标与术前比较有显著差异(均P<0.05);对照组各指标检查较治疗前比较有显著差异(均P<0.05),与对照组比较有差异显著(均P<0.05)。结论 RDN对难治性高血压患者的血压下降有良好的效果。

Objective To investigate the clinical efficacy of percutaneous radiofrequency catheter ablation of renal sympa-thetic surgery for the treatment of refractory hypertension.Methods 73 Inpatients with refractory hypertension of our hospital from October 2011 to September 2012 were chosen ,and randomly divided into RDN group and control group. Clinical efficacy blood pressure control before and after surgery and laboratory parameters of the two groups were compared.Results The total efficiency of RDN group was 91.89% ,and that of the control group was 69.44% . Follow-up found that in RDN group 1 week ,1 month ,3 months ,6 months after treatment systolic and diastolic blood pressure decreased ,the difference was statisti-cally significant （both P＜0.05）. In the control group after treatment ,blood pressure decreased slowly ,compared with RDN group. Compared with the preoperative ,each postoperative laboratory index of refractory hypertension RDN was significantly different （all P＜0.05）. Each indicator of the control group after treatment was significantly different from that before treat-ment （all P＜0.05） ,compared with the surgical group ,the difference was statistically significant （all P＜0.05）.Conclusion RDN is effective for patients with refractory hypotension to control blood pressure.