自体骨髓间充质干细胞移植治疗脑出血临床研究

Study on autologous bone marrow mesenchymal stem cells on cerebral hemorrhage

目的研究自体骨髓间充质干细胞(BMSCs)移植治疗脑出血的疗效和安全性。方法 12例脑出血患者采用鞘内注射途径移植BMSCs治疗2次;于移植前和移植后4周、3个月、6个月分别使用NIHSS评分、Barthel指数评分对疗效进行评估,同时随访移植后安全性问题;最后采用On-way ANOVA检验对试验结果进行统计学分析。结果除9例患者术后出现一过性发热,无其他不良事件发生。与术前比较,患者术后6个月的NIHSS评分显著降低(P<0.05),术后4周、3个月差异无统计学意义(P>0.05);术后3个月、6个月的Barthel指数显著升高(P<0.05),术后4周变化不明显(P>0.05)。结论自体BMSCs移植治疗脑出血安全性较好,且能促进患者的神经功能恢复,提高日常生活能力。

Objective Objective To investigate the efficacy and safety of autologous bone marrow mesenchymal stem cells transplantation in treating the cerebral hemorrhage. Methods In this study ,we twice transplanted BMSCs into 12 cases of cer-ebral hemorrhage through intrathecal injection.The National Institute of Health stroke scale and modified Barthel index were a-dopted to evaluate the neurological function and self care ability of patients before and 4 weeks ,3 and 6 months after injection.Meanwhile ,we observed the safety of BMSCs treatment during follow-up period.The one-way ANOVA Statistical method was adopted to analyze the experimental data.Results A transient fever appeared in 9 cases. Compared with before treatment ,the NIHSS was significantly decreased at 6 months（P＜0.05）and not significantly changed at 4 weeks and 3 months （P＆gt;0.05）;The Barthel was significantly increased at 3 ,6 months （P＜0.05） ,and not significantly raised at 4 weeks （P＆gt;0.05）. Conclusion It is a secure treatment that autologous bone marrow mesenchymal stem cells transplantation is performed on cerebral hemorrhage patients ,the therapeutic effect of which is to promote neurological functional recovery and improve the self care ability.