心源性恶病质患者生长激素、胰岛素、胰岛素样生长因子1信号的变化

The Change of Growth Hormone,Insulin-like Growth Factor-1,and Insulin Signal in Cardiac Cachexia

心源性恶病质是慢性充血性心力衰竭发展到后期的一个不可逆过程。它的特点是新陈代谢、炎症、内分泌途径的重构。胰岛素、生长激素和胰岛素样生长因子1(IGF-1)参与葡萄糖,蛋白质和脂类的新陈代谢过程,调节机体构成。心源性恶病质患者体内的上述三个信号受损,导致合成/分解代谢失衡。该文就近年来国内外对心源性恶病质患者生长激素、胰岛素、IGF-1信号的变化、发生机制及细胞因子对其调控的研究进行综述,以期为日后心源性恶病质的治疗提供理论依据。

Cardiogenic cachexia is an irreversible process that develops at the end stage ot chronic congestive heart failure. It is characterized by the remodeling of the metabolic, inflammatory, and endocrine pathways. Insulin, growth hormone, and insulin-like growth factor 1 （IGF-1） are involved in glucose, protein, and fat metabolism, which regulates body composition. In cardiogenic cachexia, the above three signals are impaired which causes anabolic/catabolic imbalance. Here is to make a review of the research on growth hormone, insulin, IGF-1 signal changes and mechanisms and cytokines regulation in patients with cardiac cachexia, to provide theoretical refer- ences for the future treatment.