摘要
上皮间质转化(EMT)现象是指上皮细胞通过特定程序转化获得具有间质细胞表型的过程。EMT在胚胎发生、器官纤维化和肿瘤转移过程中发挥重要作用,在原发性肝细胞癌的转移中存在这一现象。该文重点介绍Notch通路、Wnt(wingless-type)/β联蛋白通路、转化生长因子β/Smad通路和Hedgehog通路,以及转录因子Snail、Twist、ZEB-1和同源盒基因B7的组成及其在原发性肝细胞癌的EMT过程中起到的重要调控作用。EMT分子机制的研究是一个有前景的课题,可为原发性肝细胞癌的治疗提供新的靶点。
Epithelial-mesenchymal transition（EMT） is a phenomenon in which epithelial cells acquire mesenchymal characters through a specific program. EMT plays an important role in embryogenesis, organ fibrosis and tumor metastasis. EMT can be observed in metastasis of primary hepatocelluar carcinoma （HCC）. This review focuses on several signal pathways and transcription factor associated with EMT,such as Notch signal pathway, Wnt（ wingless-type ）/β-catenin, TGF-β/Smad and Hedgehog signal pathways, and Snail,Twist,ZEB-1 and HOXB7 transcription factor. A better understanding of the mechanism of EMT can help us find new targets for HCC treatment.
出处
《医学综述》
2014年第7期1205-1208,共4页
Medical Recapitulate
关键词
原发性肝细胞癌
上皮间质转化
信号通路
转录因子
肿瘤转移
Hepatocelluar carcinoma
Epithelial-mesenchymal transitions
Signal pathway
Transcrip- tion factor
Tumor metastasis
