系统性红斑狼疮合并肺部真菌感染的危险因素分析

Analysis on Risk Factors for Systemic Lupus Erythematosus Complicated by Pulmonary Fungal Infection

目的探讨系统性红斑狼疮(SLE)合并肺部真菌感染的危险因素。方法收集2009年1月至2012年1月聊城市人民医院收治的SLE患者58例,根据是否合并肺部真菌感染分为两组:合并肺部真菌感染者22例(感染组),非真菌感染者36例(非感染组)。分析SLE继发肺部真菌感染的危险因素。结果 H多因素非条件Logistic回归分析结果显示:原有狼疮性肺病、联合应用两种或两种以上抗菌药物患者、日均糖皮质激素剂量、使用抗菌药物超过2周是继发真菌感染的危险因素。结论 SLE患者应注意适量应用糖皮质激素,适时减少激素用量,适时停用抗菌药物,适当联合应用免疫抑制剂并适时停用,纠正营养不良,同时做好真菌感染的防治工作,以减少真菌感染的发生。

Objective To investigate the risk factors of systemic lupus erythematosus（SLE） complicat- ed with pulmonary fungal infection. Methods A total of 58 cases systemic lupus erythematosus patients hospitalized in Liaocheng People＇s Hospital cases from Jan. 2009 to Jan. 2012 ,were divided into two groups according to whether complicated with pulmonary fungal infection,22 cases with pulmonary fungal infection （infection group） ,36 cases without fungal infection （non-infection group）. SLE secondary pulmonary fungal infection risk factors were analyzed. Results Multivariate Logistic regression analysis showed that, the lupus disease, patients treated with combination of 2 or more antibiotics, dailygiucocorticoid dose, use of antibiotics for more than 2 weeks were the risk factors of secondary fungus infection. Conclusion The SLE patients should pay attention to the dosage of glucocorticoid,to reduce the amount of hormone at proper time,the timely withdrawal of antibiotics, combined with appropriate application and timely withdrawal of immunosuppres- sant, malnutrition correction, and the fungal infection prevention and control should be done simultaneously to reduce the incidence of fungal infection.