摘要
蛇毒丝氨酸蛋白酶是蛇毒中一类丰富的蛋白水解酶,具有重要的临床应用价值。其中一种丝氨酸蛋白酶-类激肽释放酶,作用于激肽原释放激肽,引起血管舒张,改善微循环,从而逐渐受到关注。对蛇毒中类激肽释放酶的分布、分离制备、生化性质、结构研究和药效研究等方面进行了综述,同时指出了目前存在的问题及今后的发展方向,以期为进一步的基础研究提供理论基础。
Serine proteinase is a class of abundant proteolytic enzymes in snake venom. It has important clinical practical value. Kal- likrein-like enzyme, a kind of serine proteinase acting on kininogen releasing bradykinin to cause vasodilation and improvment of micro- circulation, was focused on more and more. The paper described the distribution, separation and preparation, biochemical properties, structure and pharmacology study of the kallikrein-like enzyme from snake venoms, pointed out the current problems and future devel- opment and provided the basic theoretical for the future development.
出处
《生物学杂志》
CAS
CSCD
2014年第2期73-76,81,共5页
Journal of Biology
关键词
蛇毒
类激肽释放酶
性质
结构
功能
snake venom
kallikrein-like enzyme
character
structure
function
