藏药内服外敷治疗痛风性关节炎40例

Treatment for 40 Cases of Gouty Arthritis by Tibetan Medicine for Oral Administration and External Use

目的：观察藏药十味乳香散内服合五味甘露药浴局部熏洗治疗痛风性关节炎的临床疗效。方法：将80例患者随机分为治疗组、对照组各40例。对照组采用西药治疗：秋水仙碱：开始0.5 mg，1小时后再服用0.25 mg，2次/d，1～2 d，症状缓解后改为0.25～0.5 mg/d，共服1周，同时口服别嘌呤醇，0.1 g/次，3次/d，疗程2周。治疗组采用藏药治疗：十味乳香散，1 g/次，3次/d，饭后服，连续用药2周；五味甘露药浴配方熏洗患处2周，1次/d。观察2组关节红肿消失时间、疼痛缓解时间及治疗前后血沉、血清C反应蛋白、血尿酸、血液流变学变化情况。结果：2组治疗后关节红肿、疼痛均有缓解，治疗组缓解较对照组快，差异有统计学意义（P＜0.05）。2组血尿酸、血沉及C反应蛋白治疗前较治疗后都有明显降低（P＜0.05）；治疗后组间比较，治疗组降低较对照组明显（P＜0.05）。对照组治疗后血液流变学指标无显改善（P＞0.05），治疗组治疗后血液流变学指标改善明显（P＜0.05）；治疗后组间比较，治疗组较对照组明显降低（P＜0.05）。结论：藏药十味乳香散内服合五味甘露药浴局部熏洗治疗痛风性关节炎临床疗效显著。

Objective： To observe clinical effects of Tibetan medicine ShiWei RuXiangSan for oral administration and WuWei GanLu for local fumigation in treating gouty arthritis. Methods： Eighty patients were separated into the treatment group and the control group. The control group accepted western medicine：colchicines：start with 0.5 mg, taking 0.25mg in one hour, twice per day, one to two days, when the patients were relieved, the dose was changed into 0.25~0.5mg each day, for one week, at the same time, allopurinol orally, 0.1g each time, three times per day, one course of treatment was two weeks. The treatment group accepted Tibetan medicine： ShiWei RuXiangSan, 1 g each time, three times per day, taking after the meal, for two consecutive weeks;WuWei GanLu for local fumigation, two weeks, once per day. The disappearing time of joint swelling, pain remission time and the changes of erythrocyte sedimentation rate （ESR）, C reactive protein （CRP） in the serum, blood uric acid （BUA） and blood rheology were observed. Results：Joint swelling and pain in both groups were alleviated after treating, the re-mission of the treatment group was faster than that of the control group, the difference presented statistical meaning （P〈0.05）. BUA, ESR and CRP of both groups before treating were lower than these indexes after treating obviously （P〈0.05）;after treating, the decrease of the treatment group was more obvious than that of the control group （P〈0.05）. The indexes of blood rheology in the control group were improved obviously （P〉0.05）, and these of the treatment group were improved notably （P〈0.05）;after treating, the treatment group was lower than the control group （P〈0.05）. Conclusion：Tibetan medicine ShiWei RuXiangSan for oral administration and WuWei GanLu for local fumigation are effective in treating gouty arthritis.