摘要
从中华剑角蝗肠道共生真菌Penicillium oxalicum的发酵产物中分离得到6个苯并吡喃酮二聚体类化合物,经波谱数据及理化性质分别鉴定为secalonic acid A(1)、asperpyrones A(2)、asperpyrones B(3)、asperpyrones C(4)、asperpyrones D(5)和aurasperone A(6)。所有化合物均为首次从该属菌种中分离得到,其中化合物1对人肝癌细胞Hep G2具有显著的细胞毒活性,其IC50值为1.1μM。
Six dimerie naphthopyrones were isolated from the fermentation broth extract of Penicillium oxalicum, a fungus residing in Acrida cinerea. On the basis of spectral data and physicochemical properties, they were identified as secalonic acid A (1), asperpyrones A (2), asperpyrenes B (3), asperpyrones C (4), asperpyrones D (5) and aurasperone A (6). All the compounds were isolated from the endophytic fungus of Penicillium oxalicum for the first time. Compounds 1 showed significant cytotoxic activity against Ylep G2 with ICs0values of 1.1 μ.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第4期517-520,共4页
Natural Product Research and Development
基金
国家自然科学基金项目(21272136)
三峡大学硕士论文培优基金项目(2013PY079)