中华剑角蝗共生真菌Penicillium oxalicum中苯并吡喃酮二聚体类化合物的研究

Dimeric Naphthopyrones from Penicillium oxalicum, a Fungus Residing in Acrida cinerea

从中华剑角蝗肠道共生真菌Penicillium oxalicum的发酵产物中分离得到6个苯并吡喃酮二聚体类化合物,经波谱数据及理化性质分别鉴定为secalonic acid A(1)、asperpyrones A(2)、asperpyrones B(3)、asperpyrones C(4)、asperpyrones D(5)和aurasperone A(6)。所有化合物均为首次从该属菌种中分离得到,其中化合物1对人肝癌细胞Hep G2具有显著的细胞毒活性,其IC50值为1.1μM。

Six dimerie naphthopyrones were isolated from the fermentation broth extract of Penicillium oxalicum, a fungus residing in Acrida cinerea. On the basis of spectral data and physicochemical properties, they were identified as secalonic acid A （1）, asperpyrones A （2）, asperpyrenes B （3）, asperpyrones C （4）, asperpyrones D （5） and aurasperone A （6）. All the compounds were isolated from the endophytic fungus of Penicillium oxalicum for the first time. Compounds 1 showed significant cytotoxic activity against Ylep G2 with ICs0values of 1.1 μ.