腰椎间盘突出症血清MMP-3测定的意义

The significance of determination of Matrix Metalloproteinase-3(MMP-3)content in lumbar disc herniation

目的 进一步研究血清 MMP- 3的含量与腰椎间盘突出症发病的关系。方法 32例腰椎间盘突出症患者和 10例正常人 ,用酶免疫法测定他们血清 MMP- 3的含量。结果 腰椎间盘突出症患者血清 MMP- 3含量的平均值为 :35 .5 7ng/ml,而正常人平均值为 :2 7.5 6 ng/ml,两者的差异有显著性意义 (P<0 .0 1)。其中脱出型腰椎间盘突出症患者的血清 MMP- 3含量明显高于非脱出型患者 (P<0 .0 5 )。结论 血清 MMP- 3的测定可作为对腰椎间盘突出症的辅助诊断 ,并且证实血清 MMP-

Objective To investigate the relationship between sero matrix mefalloproteinase 3(MMP 3) content and lumbar disc herniation Method The sero MMP 3 content in 32 patients with lumbar disc herniation and 10 normal human were determined with enzyme immunoassay method Result The mean sero MMP 3 content in lumbar disc herniation was 35 57ng/ml,while normal human27 56ng/ml,the deference was siginificant ( P <0 01) However the sero MMP 3 content in lumbar disc prolapsus was siginificantly higher than that in nonprolapsus ( P <0 05) Conclusion The determination of sero MMP 3 content can be used as assistant diagnosis of the lumbar disc herniation,furthermore confirm the relationship between sero MMP 3 content and degree of lumbar disc degeneration