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眼部γδT细胞研究进展 被引量:1

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摘要 γδT细胞是近年来人们新认识的一种表型和功能独特的T淋巴细胞亚群。主要分布于皮肤、小肠、肺、生殖道、泌尿道等各种器官、组织的上皮层,在机体抗感染、抗肿瘤、抗过敏及上皮损伤、修复中发挥重要作用,并可能在抵御广谱微生物人侵的一线防御中起关键作用。目前,γδT细胞的研究主要集中在呼吸道、肠道以及皮肤等领域。经研究发现,在角膜和结膜上皮组织内也有叫8T分布,眼部γδT细胞可以直接或间接促进某些细胞因子表达并通过这些细胞因子间、细胞因子与相关受体等相互作用发挥抗感染、抗肿瘤、抗角膜移植排斥、角膜上皮及神经损伤修复等作用。但γδT在这些部位的研究却相对较少。文中就γδT细胞在眼部中的研究做一简述。
出处 《中国实用眼科杂志》 CSCD 北大核心 2014年第4期403-407,共5页 Chinese Journal of Practical Ophthalmology
基金 国家自然科学基金(81170831) 河南省基础与前沿计划(102300410024、112300410036、112300410093) 河南省医学科技攻关项目(201203171)
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