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粪便菌群移植在炎症性肠病治疗中的应用 被引量：9

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摘要 IBD是病因尚不明确的肠道非特异性炎性疾病。遗传、饮食、肠道共生菌、黏膜屏障功能、固有和适应性免疫等因素均与其发病有着不同程度的联系。胃肠道是人体最大的细菌聚集地，有数量超过1×10^4的细菌，是人体全身细胞数的10倍。有研究提示IBD患者的微生物菌群和健康者存在差异，但目前尚未发现确切的致病菌种。临床上通过使用益生菌和益生元调节肠道菌群的组成进而改善疾病的严重程度，这已成为IBD的重要辅助疗法。
作者 戴张晗 郑青 冉志华
机构地区 上海交通大学医学院附属仁济医院消化科上海市消化疾病研究所上海市炎症性肠病研究中心
出处 《中华消化杂志》 CAS CSCD 北大核心 2014年第4期283-285,共3页 Chinese Journal of Digestion
关键词 炎症性肠病 粪便菌群 应用 治疗 移植 炎性疾病 适应性免疫 微生物菌群
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献23

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同被引文献53

  • 1Stephen J Halpin,P John Hamlin,Daniel P Gree,Lisa Warren,Alexander C Ford.Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience[J].World Journal of Gastroenterology,2013,19(7):1091-1097. 被引量：1
  • 2中华医学会消化病学分会炎症性肠病协作组,欧阳钦,胡品津,钱家鸣,郑家驹,胡仁伟.对我国炎症性肠病诊断治疗规范的共识意见(2007年，济南)[J].中华消化杂志,2007,27(8):545-550. 被引量：1024
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  • 4Brandt LJ,Aroniadis OC, Mellow M,et al. Long-term follow-up of co|onoscopic fecal microbiota transplant for recurrent Clostridium difficile infection[J]. Am J Gastroenterol,2012,107 (7) : 1079-1087.
  • 5Borody TJ,Khoruts A. Fecal microbiota transplantation and e- merging applications[J].Nat Rev Gastroenterol Hepatol,2012,9 (2) :88-96.
  • 6Gough E,Shaikh H,Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection[J].Clin Infect Dis,2011,53(10): 994-1002.
  • 7Trubiano JA,Gardiner B,Kwong JC,et al. Faecal microbiota transplantation for severe Clostridium difficile infection in the intensive care unit [J ]. Eur J Gastroenterol Hepatol,2013,25 (2) :255-257.
  • 8Persky SE,Brandt LJ. Treatment of recurrent Clostridium diffi- cile-associated diarrhea by administration of donated stool directly through a colonoscope[J]. Am J Gastroenterol,2000, 95 ( 11 ) : 3283-3285.
  • 9Kunde S,Pham A,Bonczyk S,et al. Safety,tolerahility,And clinical response after fecal transplantation in children and young adults with ulcerative colitis[J]. J Pediatr Gastroenterol Nutr,2013,56(6) :597-601.
  • 10Borody T. J, Khoruts A. Fecal microbiota transplan- tation and emerging applications [ J ]. Nat Rev Gas- troenterol Hepato1,2011,9 (2) :88 - 96.

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中华消化杂志
2014年 第4期

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