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PIN1及其调控与胶质瘤 被引量：2

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摘要 胶质瘤是颅内常见的恶性肿瘤,预后差,彻底治愈仍是医学难题之一。肽基脯氨酰异构酶1(PIN1)是一种多肽脯氨酰异构酶,能特异性催化磷酸化的丝、苏-脯氨酸发生顺反异构。PIN1在多种肿瘤组织中过度表达,称为肿瘤发生的催化因子,与胶质瘤的发生密切相关。一旦明确PIN1相关通路调控胶质瘤的具体机制,可能成为胶质瘤治疗的新靶点。
作者 倪升远 牛朝诗
机构地区 合肥安徽医科大学附属省立医院神经外科脑功能与脑疾病安徽省重点实验室 安徽省脑立体定向神经外科研究所
出处 《中国微侵袭神经外科杂志》 CAS 2014年第4期187-189,共3页 Chinese Journal of Minimally Invasive Neurosurgery
基金 国家自然科学基金项目(编号:81172407) 安徽省重点实验室绩效考核项目(编号:1306c083028)
关键词 神经胶质瘤 肽基脯氨酰异构酶 基因表达调控
分类号 R739.41 [医药卫生—肿瘤]
  • 相关文献

参考文献19

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  • 2Mortenson DE, Kreitler DF, Yun HG, et al. Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pinl WW domain [J]. Acta Crystallogr D Biol Crystallogr, 2013, 69(Pt 12): 2506-2512.
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二级参考文献43

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共引文献17

同被引文献32

  • 1Yang Y,Niu CS,Cheng CD,et al.Pin1-Nanog expression in human glioma is correlated with advanced tumor progression[J].Oncol Rep,2013,30(2):560-566.
  • 2Uchida T,Takamiya M,Takahashi M,et al.Pin1 and Par14peptidyl prolyl isomerase inhibitors block cell proliferation[J].Chem Biol,2003,10(1):15-24.
  • 3Fang KM,Yang CS,Lin TC,et al.Induced interleukin-33expression enhances the tumorigenic activity of rat glioma cells[J].Neuro Oncol,2014,16(4):552-566.
  • 4Liu Z,Niu Y,Xie M,et al.Gene expression profiling analysis reveals that DLG3 is down-regulated in glioblastoma[J].J Neurooncol,2014,116(3):465-476.
  • 5Khanal P,Kim G,Lim SC,et al.Prolyl isomerase Pin1negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer[J].FASEB J,2013,27(11):4606-4618.
  • 6Ayala G,Wang D,Wulf G,et al.The prolyl isomerase Pin1is a novel prognostic marker in human prostate cancer[J].Cancer Res,2003,63(19):6244-6251.
  • 7Nakashima M,Meirmanov S,Naruke Y,et al.Cyclin D1overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression[J].J Pathol,2004,202(4):446-455.
  • 8Jamiyandorj U,Bae JS,Noh SJ,et al.Expression of peptidyl-prolyl isomerase PIN1 and its role in the pathogenesis of extrahepatic cholangiocarcinoma[J].Oncol Lett,2013,6(5):1421-1426.
  • 9Ryo A,Hirai A,Nishi M,et al.A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx[J].J Biol Chem,2007,282(50):36671-36681.
  • 10Atkinson GP,Nozell SE,Harrison DK,et al.The prolyl isomerase Pin1 regulates the NF-kappa B signaling pathway and interleukin-8 expression in glioblastoma[J].Oncogene,2009,28(42):3735-3745.

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中国微侵袭神经外科杂志
2014年 第4期

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