自噬发生中的ROS调节机制

The Role of Reactive Oxygen Species in Autophagy

活性氧是细胞代谢中产生的有很强反应活性的分子,易将邻近分子氧化,并参与细胞内多种信号转导途径,对相关生理过程进行调控.自噬是真核细胞通过溶酶体机制对自身组分进行降解再利用的过程,在细胞应激及疾病发生等过程中发挥重要作用.本文对活性氧和自噬相关调节进行分类介绍,根据新近研究进展,从活性氧参与的自噬性死亡、自噬性存活以及线粒体自噬3方面探讨了相关信号转导机制,对活性氧作为信号分子参与的自噬调控途径做一总结和介绍.

Reactive oxygen species （ROS） are highly reactive molecules produced in cell metabolism, thus make surrounding molecules vulnerable to oxidation. ROS are involved in various intracellalar signal transduction pathways, and are believed to be important regulators of physiological processes. Autophagy is the degradation and recycling of components in eukaryotes through the lysosome system, and is a key player in cellular response to stress and the pathogenesis of related diseases. In this paper we reviewed the latest studies about ROS and autophagy-related regulation, focusing on autophagy modulation mediated by ROS as signal molecules, especially on signal transduction mechanisms involved in ROS induced autophagic cell death, autophagic cell survival and mitophagy.