斯钙素在哺乳动物骨组织代谢中的作用

The Role of Stanniocalcin in Mammalian Bone Metabolism

斯钙素(stanniocalcin,STC)是一种最早在硬骨鱼中发现的糖蛋白类激素.哺乳动物斯钙素在体内钙磷代谢、肌肉骨骼系统的发育等方面均起到重要作用,并且在心血管疾病、肿瘤发展以及神经系统疾病中也扮演重要角色.近年,斯钙素在骨骼发育中的作用逐渐引起科学界的关注.骨组织中STC由成软骨细胞、成骨细胞分泌,并以自分泌/旁分泌的形式作用于局部组织细胞中,主要影响软骨形成和骨重建过程.本文以斯钙素为主题,综述了其生化分子特性、其在骨组织中的表达分布特点,以及该分子在成熟骨组织骨重建过程中的作用机制.本文将为深入了解斯钙素在骨组织代谢中的作用提供帮助.

Stanniocalcin （STC） is a glycoprotein hormone initially reported in endocrine gland of bony fish. Mammalian STC plays an important role in the regulation of calcium/phosphate homeostasis and the development of musculoskeletal system. Abnormal STC can be found in cardiovascular disease, progression tumors and neurodegenerative disease. In recent years, the role of STC in mammalian bone development has especially interested researchers. Vertebrate STC secreted by chondrocytes or osteoblasts acts on local tissues or ceils through a paracrine/autocrine way, and primarily influenced on cartilage formation and bone mineralization. This review introduces the molecular characteristics of STC1 and STC2, including their expression and distribution. The mechanisms of STC actions in bone remodeling and associated signal pathways are discussed.