应用红外热像诊断系统评价左归丸、右归丸及其拆方药物靶向性的研究

Assessing Drug Targeting of Yougui Pill,Zuogui Pill,and Their Disassembled Prescriptions Using Infrared Thermography

目的应用红外热像诊断系统对左归丸、右归丸及其拆方药物的靶向性进行动态评价研究。方法采用自身对照试验，募集5名健康志愿受试者，分别在其服用温水、左归丸、右归丸及其拆方药粉的第30、70、100、130、160 min，采用红外热像诊断系统对每位受试者采集全身10～11幅热像图，完成共计125例次的扫描后，对下腹、子宫、督脉、神阙4个区位的热值进行数据分析。结果（1）服用右归丸及其拆方第30 min时在不引起下腹热值增高的前提下可提高督脉区位和神阙区位热值。（2）服用左归丸及其拆方全程均降低督脉、神阙、下腹、子宫区位热值。结论左归丸、右归丸的药物靶向性集中在督脉和神阙区位，并非直接针对于下腹、子宫区位。

Objective To dynamically assess drug targeting of Yougui Pill （YP） and Zuogui Pill （ZP） using infrared thermography. Methods In this self-control experiment, five healthy volunteers were recruited. By using infrared thermography 10 to 11 thermal images of different body locations were taken from each participant after they took warm water, YP, ZP, and their dissembled prescriptions at 30, 70, 100,130, and 160 m in, respectively. The heat values in the lower quadrant abdomen, uterus, Du channel, and Shenque （CV8） were statistically analyzed after scanning for 125 times. Results Administration of YP and its disassembled prescriptions enhanced the heat value of the locations of the Du channel and Shenque （CV8）, but did no enhance the heat value of the lower quadrant abdomen at 30 min. Administration of ZP and its disassembled prescriptions reduced the heat value in the locations of the lower quadrant abdomen, uterus, Du channel, and Shenque （CV8） at each time point. Conclusion The drug targeting of ZP and YP focused on the locations of the Du channel and Shenque （CV8）, not on the locations of the lower quadrant abdomen or uterus.