TIA患者颈动脉粥样硬化与溶血磷脂酸、D-二聚体的相关性研究

The study in the correlation with carotid atherosclerosis of the patients with TIA and lysophosphatidic acid and the D-dimer

目的探讨TIA患者颈动脉粥样硬化与溶血磷脂酸(LpA)、D-二聚体(DD)的相关性。方法选择196例TIA患者,同时选择120例健康者作为对照组。由两位B超室副主任医师进行颈动脉超声检查,观察颈动脉内膜厚度、回声强度,观察颈动脉有无斑块,斑块的部位、形状、大小及表面是否有溃疡等。结果 TIA患者组的LpA、DD水平均显著高于健康者组,两者比较差异有统计学意义(P<0.05),随着颈动脉粥样硬化的严重程度的增加,LpA、DD水平有逐渐增加的趋势;通过不同斑块性质的比较发现,各组间LpA、DD水平均P<0.05,DD水平与斑块的稳定性有关。结论颈动脉粥样硬化的发生与LpA、DD水平相关,颈动脉粥样硬化的程度与LpA、DD水平相关,LpA、DD水平在一定程度上可反映颈动脉粥样硬化的进展情况。

Objective To explore the correlation with carotid atherosclerosis of the patients and lysophosphatidic acid, the D-dimer.Methods 196 cases of the TIA patients were choosed as TIA group , and 120 cases of healthy persons were choosed as control group .Carotid ultrasound examination was operated by the same ultrasound doctor, and observed the intima-media thickness of carotid artery and echo intensity , observed with or without plaque of carotid artery , and plaque location , shape, size and surface whether there was ulcers .Results The levels of lysophosphatidic acid, D-dimer with patients were significantly higher than the healthy group , the difference was significant（P〈0.05）, and accompanied by the increase in the severity of carotid atherosclerosis , its levels had a growing trend.By comparison of the different nature of plaque , the levels of lysophosphatidic acid , D-dimer among the groups were significant differences （ P〈0.05） , and the levels of D-dimer levels were related with＆nbsp;the stability of the plaque .Conclusion The levels of lysophosphatidic acid and D-dimer are related the occurrence with carotid atherosclerosis; The levels of lysophosphatidic acid and D-dimer are related the extent with carotid atherosclerosis;To a certain extent ,the levels of lysophosphatidic acid and D-dimer can reflect the progress of carotid atherosclerosis .