青年缺血性脑卒中与血脂代谢异常关系的分析

The relationship between ischemic stroke and abnormal lipid metabolism in young patients

目的探讨青年缺血性脑卒中与血脂代谢异常之间的关系,并评价其危险因素。方法对56例青年缺血性脑卒中患者、52例年龄匹配的青年健康对照组;59例老年缺血性脑卒中患者、54例年龄匹配的老年健康对照组的血脂、血糖及血压等指标进行分析。结果青年缺血性脑卒中患者的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)含量显著高于青年对照组(P<0.05);高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A含量低于青年对照组(P<0.05)及老年缺血性脑卒中组(P<0.05)。结论脂质代谢异常是引起青年缺血性脑卒中的主要因素之一,其中HDL-C降低可能是缺血性脑卒中最重要的危险因素。

Objective To investigate the relationship between ischemic stroke and abnormal lipid metabolism in young patients ,and evaluate its risk factors .Methods We evaluated the level of lipid ,blood glucose , blood pressure and others in 56 young patients with ischemic stroke ,52 age-matched young healthy controls ,59 elderly patients with ischemic stroke and 54 age-matched elder healthy controls .Results The level of total cholesterol（TC）,triglyceride （TG） and low density lipoprotein-cholesterol （LDL-C）in young patients with ischemic stroke was higher than that in young control group （ P 〈0.05 ） .The level of high density lipoprotein-cholesterol （ HDL-C） and apolipoprotein A （ Apo-A） was lower than that in young control group and elderly group with ischemic stroke（ P〈0.05）.Conclusion The abnormal lipid metabolism is the major factor of ischemic stroke in young patients,and the reduction of HDL-C is probably the most important risk factor of ischemic stroke .