神经调节素1-ErbB4信号通路在突触形成过程中的作用

The Role of Neuregulin 1-ErbB4 Signaling in Synaptogenesis

nrg1和erbb4参与神经系统发育的多个环节,包括在神经元增生、迁移和分化,神经突起的生长和轴突导向,以及突触形成和可塑性等过程中发挥重要作用.同时,nrg1和erbb4还是精神分裂症的2个主要易感基因,在精神分裂症的发病中具有重要作用.抗精神分裂症药物也可能通过作用于神经调节素1-ErbB4信号通路而起到治疗的作用.因此,该信号通路由于其在突触和神经环路发育中的重要作用而备受关注,也成为当前开发新型抗精神分裂症药物的一个重要靶点.

Neuregulin 1 （NRG1）-ErbB4 signaling has been hypothesized to play a pivotal role in mediating diverse neural developmental processes ranging from neural proliferation and migration to neurite outgrowth and synapse formation. Both nrgl and erbb4 are candidate risk genes for schizophrenia and are regarded to play important roles in schizophrenia. Recent findings suggest that antipsychotics may function through ErbB4 signals. Thus, much attention has been focused on the functions of NRG1-ErbB4 signaling in synapse and neural circuit development. ErbB4 signals have thus become a potential target for novel antipsychotic treatments.