乳腺癌相关雄激素受体的研究进展

Recent progression on androgen receptor in breast cancer

雌激素、孕激素受体和人表皮生长因子受体2的表达水平与乳腺癌预后关系密切,是治疗乳腺癌的重要靶点。研究发现,雄激素受体(AR)与乳腺癌的发生、发展、复发、转移及预后转归相关,可能成为影响乳腺癌预后的一个指标。目前,AR在乳腺癌领域的研究陆续展开,已成为一个新的热点。本文就AR与乳腺癌关系的研究现状作初步探讨。

The expressions of estrogen receptor,progesterone receptor and human epidermal growth factor receptor 2 are not only closely associated with the prognosis of breast cancer, but also can be served as targets for breast cancer therapy. Recent studies have found that androgen receptor（ AR） is associated with the occurrence, development, relapse and metastasis, as well as the progno-sis and outcome in breast cancer, and may be a prognostic predictor. Currently, AR in breast cancer is becoming a hot spot. In this pa-per, we make a preliminary discussion on relationship between AR and breast cancer.