血浆一氧化氮浓度在正常高值血压及原发性高血压患者中的变化探讨

Levels of serum nitric oxide in prehypertension and hypertension patients

目的观察正常高值血压患者、原发性高血压（EH）患者血浆一氧化氮（NO）浓度的变化，探讨其在高血压发生、发展过程中的意义。方法选择2013年5月至2013年8月在石河子大学医学院第一附属医院体检科参加健康体检的高血压患者163例为高血压组。同时，选择同期参加健康体检的血压正常者221例，其中61例血压〈120／80mmHg者为正常对照组；160例血压120—139mmHg／80～89mmHg为正常高值血压组。检测人选者常规生化指标及血浆NO浓度。结果正常高值血压组血浆N0高于正常对照组，差异有统计学意义（P〈0．05）。高血压患者血浆NO低于正常对照组和正常高值血压组，差异有统计学意义（P〈0．05）。正常高值血压危险因素的多因素Logistic回归分析显示，正常高值血压与体重指数、甘油三酯、低密度脂蛋白胆固醇、血糖、一氧化氮呈正相关。结论NO在原发性高血压发生、发展中均具有重要意义。

Objective To observe the levels of nitric oxide （NO） in prehypertension and hypertension patients. Methods Three groups were recruited from subjects of regular health checkup in the First Affiliated Hospital of Medical College of Shihezi University from May to October, 2013. Essential hypertension（EH） group （n=163）, prehypertension group（PH） （n=160）, and normotensive （NT） control group （n=61）. The levels of NO were compared by biochemical tests. Result Compared with NT group, plasma NO level in the PH group was significantly higher （58.81±26.10 vs 62.93±23.84, P〈 0.05）, In the EH group, plasma NO were significantly lower than those in the NT group （P〈0.05）. Logistic analysis indicated that BMI, TC, LDL-C, glucose, NO were related to the hypertension. Conclusion Plasma NO might play important role in the pathogenesis and development of hypertension.