布地奈德雾化吸入联合序贯疗法治疗儿童支原体肺炎112例疗效观察

Investigation on effect of nebulized budesonide inhalation combined with sequential therapy in treatment of Mycoplasma pneumoniae pneumonia in 112 children cases

目的观察布地奈德混悬液雾化吸入联合序贯疗法治疗儿童支原体肺炎的疗效。方法将224例支原体肺炎患儿随机分为对照组和治疗组,对照组112例予序贯疗法治疗,治疗组112例在对照组治疗的基础上加用布地奈德混悬液雾化吸入治疗,观察两组疗效及不良反应。结果治疗组显效率明显高于对照组(P<0.05);治疗组发热、咳嗽、肺部啰音消失及住院时间均少于对照组(P<0.01);治疗组在治疗过程中未发现与布地奈德混悬液相关的不良反应。结论布地奈德雾化吸入联合序贯疗法治疗儿童支原体肺炎可有效缓解患儿临床症状、缩短病程,安全有效。

Objective To investigate the effect of inhalation of nebulized budesonide combined with sequential therapy in treatment of Mycoplasma pneumoniae pneumonia in children. Methods 224 cases of children with Mycoplasma pneumoniae pneumonia were randomly divided into two groups. The 112 children in control group were treated with sequential therapy while the other 112 children in treatment group were treated with sequential therapy combined with inhalation therapy of nebulized budesonide suspension. The efficacy and adverse reaction of the treatment in both groups was investigated. Results The efficacy of the treatment group was significantly higher than that of control group （P〈0.05）. The average recovery time of fever, cough and pulmonary rales and the hospitalization duration in treatment group were shorter than those in control group （P〈0.01）. No adverse reaction related to budesonide suspension inhalation was found in treatment group during the treatment. Conclmion Inhalation of nebulized budesonide combined with sequential therapy can effectively relieve the clinical symptoms and shorten the course of disease with proper safety in treatment of children with Mycoplasma pneumoniae pneumonia.