南充地区抗结核药物导致肝损害的调查分析

Clinical analysis of the antituberculosis drug induced liver injury in Nanchong

目的调查分析抗结核药物诱导肝损害的临床特点。方法回顾性调查分析2008年2月至2012年3月在南充地区医院进行抗结核治疗患者的肝功能情况。结果符合本次调查标准的患者共2 136例,其中203例发生肝损害,发生率为9.50%;在203例肝损害患者中,180例(88.67%)发生于60d内;135例患者出现肝炎的典型表现(66.50%),68例患者则全无症状(33.50%),是在肝功能检查时发现异常。经治疗,189例(93.10%)患者痊愈或好转,14例(6.90%)患者未愈。结论抗结核药物导致的药物性肝损害应引起重视,对其应注意预防、早期诊断和及时合理的治疗。

DENG Xue-li, QUAN Feng-qiong, CHEN Jie, YANG Si-yun （ The Central Hospital of Nanchong City, Sichuan, Nanchong 637000, China） Objective To analyze the clinical characteristics of liver injury induced by antituberculosis drug. Method The tuberculosis patients treated in Nanchong hospital during the period from February, 2008 to March, 2012, were collected and analyzed of the prevalenee of liver injury induced by antituberculosis drug. Results 2 136 eases were collected in the survey, and there were 203 cases （9.50%） who were demonstrated antituberculosis drug-induced liver injury.180 patients developed the reaction within 60 days, accounting for 88.67%.Of the 203 cases, 135 emerged related hepatitis symptoms, 68 patients were all asymptomatic, and only found abnormalities in liver function examination. 189（93.10%） experienced normalization or markedly improved of the liver function,and 14 cases （6.90%） showed poor effects. Conclusions Liver injury induced by antituberculosis drugs was a severe problem which should be attentive by clinician.Its prevention, early diagnosis and proper treatment were of utmost importance and should be emphasized.