YB-1在中晚期宫颈癌组织中的表达及其临床意义

The Expression and Its Clinical Significance of YB-1 in Advanced Cervical Cancer

目的研究YB-1在中晚期宫颈癌组织中的表达及其与临床病理特征的关系,探讨YB-1在宫颈癌侵袭、转移和进展中的作用.方法采用免疫组化法检测中、晚期宫颈癌组织微阵列芯片78例组织标本中YB-1的表达情况,分析其表达与宫颈癌淋巴转移、FIGO分期、分化程度的关系.结果 (1)78例宫颈癌组织中YB-1的阳性表达率为24/78(30.8%);(2)YB-1在宫颈癌组织中表达与FIGO分期和分化程度密切相关,随着FIGO分期的变晚、分化程度的降低其表达逐渐增高(P<0.05);YB-1在宫颈癌组织中表达与淋巴转移无关,有淋巴转移组和无淋巴转移组YB-1表达差异无统计学意义(P>0.05).结论 YB-1在宫颈癌组织中表达可能与宫颈癌的局部侵袭、转移和进展密切相关.

To study the expression of YB-1 in advanced cervical cancer tissues and the relationship between its expression and the clinicopathological characteristics, to investigate the role of YB-1 in cervical cancer invasion, metastasis and progress. Methods Immunohistochemistry was used to detect the expression of the YB-1 in 78 cases of middle and advanced stage cervical cancer tissue microarray chip and the relationship between its expression and the lymphatic metastasis, FIGO stage and the differentiated degree were analyzed. Results （1） The positive expression of YB-1 in cervical cancer was 24/78 （30.8%） （2） The expression of YB-1 in cervical cancer was significantly related to FIGO stage and differentiation degree respectively. With the increase of FIGO stage and the decrease of differentiation degree, the expression of YB-1 increased gradually （P〈0.05） ; The expression of YB-1 in cervical cancer was not significantly related to the lymph node metastasis. There was no significant difference between the lymph node metastasis positive and negative group （P〉 0.05） . Conclusion The expression of YB-1 may be closely related to the local invasion, metastasis and progress of cervical cancer.