牙周基础治疗从不同途径对伴中重度牙周炎冠心病患者的影响

The Effect of Initial Periodontal Treatment on Patients with Coronary Heart Disease Combined with Moderate/Severe Chronic Periodontitis from Different Ways

目的比较牙周基础治疗后伴有中重度慢性牙周炎的冠心病患者血清促炎因子水平及牙周可疑致病菌检出率的变化,分析牙周基础治疗对冠心病发生风险的影响.方法伴有中重度慢性牙周炎的冠心病患者80例,随机分为心内科常规治疗及牙周治疗组(实验组)和心内科常规治疗组(对照组),8周后比较2组患者血清促炎因子水平及牙周可疑致病菌的检出率变化.结果 2组患者牙周可疑致病菌检出率明显下降(P<0.05),实验组血清IL-1β及TNF-α水平明显降低(P<0.01).结论牙周基础治疗能从不同途径降低冠心病的发生风险,有利于冠心病的防治.

Objective To compare the effect proinflammarry factors in patients with coronary heart of initial periodontal treatment on level changes of serum disease combined with chronic periodontitis. Methods Eighty coronary heart disease patients with moderate/severe periodontitis were recruited and divided into two groups randomly. The experimental group was treated with the routine medicine plus initial periodontal treatment, while the control group treated with the routine treatment only. Periodontal clinical index, detective radio of putative periodontopathic bacteria and serum IL-1β and TNF-α level were observed 8 weeks after periodontal therapy, respectively. Results All patients demonstrated improvement of periodontal clinical index and the relevance ratio of putative periodontopathie bacteria decreased. The level of IL-1 β and TNF-α in experimental group decreased significantly. Conclusion Initial periodontal treatment can reduce the occurrence risk significantly from different ways, which is helpful to the prevention and treatment of CHD.