BIAsp30与BHI30胰岛素对老年2型糖尿病患者血糖控制能力的临床观察

Comparative Study on the Control of Blood Glucose by BIAsp30 and BHI30 Insulin for Elderly Patients with Type 2 Diabetes

目的对比观察BIAsp30与BHI30胰岛素对老年2型糖尿病患者血糖的控制能力.方法选择老年2型糖尿病患者80例,观测分别用BIAsp30与BHI30胰岛素药治疗前后早餐前后、午餐前后和晚餐前后的血糖动态变化及低血糖不良反应发生率.结果血糖控制效果:观察组患者与对照组治疗前后的各项观察指标差异无统计学意义(P>0.05);观察组患者经治疗后空腹血糖、餐后2 h血糖和糖化血红蛋白水平均低于治疗前(P<0.05);对照组患者经治疗后空腹血糖、餐后2 h血糖和糖化血红蛋白水平均低于治疗前(P<0.05).血糖动态监测:观察组患者早餐后峰值和晚餐后峰值均明显低于对照组患者水平(P<0.05).低血糖不良反应发生率:观察组患者不良反应发生率(5%)低于对照组患者(12.5%).结论 BIAsp30皮下注射给药对治疗老年2型糖尿病患者较BHI30具有更强的血糖控制能力.

Objective To compare the control ability of BIAsp30 and BHI30 insulin on blood glucose in elderly patients with type 2 diabetes mellitus. Methods We selected 80 elderly patients with type 2 diabetes, and divided them into two groups： observation group and control group. Patients in the two groups were treated by BIAsp30 and BHI30 insulin, respectively, then the change of blood glucose and incidence rate of hypoglycemia were observed before and after insulin treatment, before and after breakfast, lunch and dinner. Results The effect of blood glucose control： There was no significant difference in all indexes between two groups before and after the treatment （P〉0.05） ; The fasting blood glucose, postprandial 2 hour blood glucose and glycosylated hemoglobin levels of patients in observation group and control group were lower than those before treatment （P 〈0.05） Monitoring of blood glucose dynamics： The peak value of blood glucose of patients in observation group after breakfast and dinner were significanfly lower than the control group （P〈0.05） . The incidence of hypoglycemia：The incidence of hypoglycemia in patients in the observation group （5%） was lower than that of the control group （12.5%） Conclusion Subcutaneous injection of BIAsp30 insulin has stronger ability to control blood glucose than BHI30 in treatment of elderly patients with type 2 diabetes.