EORTC评分对二次经尿道电切膀胱肿瘤的指导价值

The guidance value of EORTC score for second transurethral resection of the bladder tumor

目的研究欧洲癌症研究治疗协会(EORTC)评分对膀胱肿瘤实施二次经尿道膀胱肿瘤电切术(TURBT)的指导价值。方法对78例表浅性膀胱肿瘤患者随机分组,第一次TURBT术后分别行EORTC评分,其中实验组术后4周行二次TURBT,术后膀胱灌注相同。所有患者随访2年,比较2组间膀胱肿瘤进展率和复发率。结果实验组复发评分中危21例(53.8%),高危10例(25.6%),进展评分中危22例(56.4%),高危11例(28.2%);对照组复发评分中危20例(51.2%),高危9例(23.1%),进展评分中危21例(53.8%),高危10例(25.6%)。实验组的肿瘤复发和进展例数为3例、4例,而对照组为12例、14例,2组间比较有统计学差异。结论二次TURBT能降低NMIBC患者的进展率和复发率;EORTC评分对指导二次TURBT有一定意义,最终结论尚需大样本研究验证。

Objective To explore the guidance value of EORTC score for the second transurethral resection of the bladder tumor （TURBT） operation. Methods A total of 78 cases of superficial bladder tumor were randomly divided into two groups. After the first TURBT, EORTC was scored. The experimental group underwent a second TURBT 4 weeks after oper- ation. Both groups received the same intravesical instillation. All patients were followed up for 2 years. The rate of progression and recurrence of bladder tumor were compared between two groups. Results The middle risk and the high risk of recurrence score in the experimental group and control group were 21, 10 and 20, 9 respectively. The middle risk and the high risk of pro- gression scores were 22,11, and 21,10 respectively. There were 3 cases of recurrence and 4 cases of progression in the experi- mental group; and 12 cases of recurrence and 14 cases of progression in the control group, with a significant difference between the two groups. Conclusions The second TURBT can reduce progression rate and recurrence rate in NMIBC patients. EORTC score has a significant guidance for the second TURBT, but the final conclusions still need to be verified in studies with large samples.