心肌缺血相关炎症因子的研究进展

Inflammatory factors related to myocardial ischemia： research progress

炎症在冠状动脉粥样硬化（CAS）引起心肌缺血的过程中起着关键作用，与缺血性心脏病的发生、发展、诊断、治疗和预后密切相关的炎症标志物有C反应蛋白、细胞因子、细胞黏附分子、趋化因子等。心肌缺血病理生理的基础是冠状动脉粥样斑块不稳定，发生破裂继之血栓形成，部分或完全堵塞病变的血管，从而导致不同程度的心肌缺血损伤，引发一系列病理症状。本文就C反应蛋白、白细胞介素、肿瘤坏死因子-α和转化生长因子-β在CAS性心肌缺血的促发、介导以及维持等方面的研究进展和临床意义作一综述。

Inflammation plays a key role in the process of myocardial ischemia caused by coronary atherosclerosis （CAS）. The occurrence, development, patho-physiological changes, diagnosis, treatment and prognosis of ischemic heart disease are closely related to the inflammatory markers, such as C-reactive protein （CRP）, cytokines, cell adhesion molecules, chemokines, and so on. The patho-physiological basis of myocardial ischemia is due to instability of coronary atherosclerotic plaque, rupture followed by thrombosis, and partial or completed occlusion of the injured vessels. Then with various extensions, it will cause myocardial ischemic injury and lead to a series of pathological symptoms. In this article, we reviewed 4 inflammatory markers： CRP, interleukins （IL）, tumor necrosis factor-α（TNF-α） and transforming growth factor-β （TGF-β）, and elucidated their research progress and clinical significances in the induction, mediation and maintenance of coronary atherosclerotic myocardial ischemia.