人Toll样受体9基因启动子区的生物信息学分析

Bioinformatics Analysis of the Human TLR9 Gene Promoter Region

目的:探讨人Toll样受体9(TLR9)基因启动子区序列特征。方法:利用生物信息学技术预测人TLR9基因启动子区域、转录因子结合位点和CpG岛分布。结果:人TLR9基因启动子区有1434个转录因子结合位点,人和小鼠保守区域内存在23个共同的转录因子结合位点,人TLR9基因启动子区包含长572 bp的CpG岛。结论:人TLR9基因启动子区相关生物信息学的研究,提高了针对启动子的研究效率,并为预测基因启动子的功能提供了重要信息。

Objective： To investigate character of Toll-like receptor 9（TLR9） gene promoter. Methods： Bioinfor matics technology was used to predict the promoter region, transcriptional binding sites and distribution of CpG is land of human TLR9 gene. Results： There were 1434 transcriptional factor binding sites in human promoter re gion. 23 same transcriptional factor binding sites in human and mouse＇s conserved sequences were identified. And, a 572 bp CpG island was found in human TLR9 gene promoter region. Conclusion： Gene promoter related bioin formatics cannot only improve the efficiency of gene promoter research, but provide significant information for the prediction of zene promoter function.