抗逆转录病毒治疗对中国HIV感染者IL-7/IL-7R的影响

The effect of anti-retroviral therapy on interleukin （IL）-7/IL-7R in HIV infected patients in China

目的 探讨抗逆转录病毒治疗对中国HIV感染者IL-7/IL-7R的影响.方法 选取HIV感染者35例,健康对照者30例.对HIV感染组治疗前、治疗1年后及健康对照组血浆IL-7水平、CD4＋、CD8＋T细胞上IL-7R（CD127）的表达、CD4＋T细胞数量进行分析比较.结果 中国HIV感染者治疗前血浆IL-7水平[（8.98±3.77） pg/ml]较健康人群[（3.84±0.86）pg/ml]升高（P＜0.05）,CD4＋T细胞[（202.65±121.54）个/μl]、CD4＋ CD127＋T细胞[（60.25±11.75）％）]及CD8＋CD127＋T细胞[（46.27±12.10）％]则较健康人群[（766.99±103.21）个/μl、（76.89 ±20.01）％、（81.27±12.35）％]下降（P＜0.05）.抗逆转录病毒治疗（ART）治疗后血浆IL-7水平[（5.55±1.35） pg/ml]较治疗前下降（P＜0.05）,CD4＋T细胞[（450.58 ±152.85）个/μl]、CD4＋ CD127＋T细胞[（69.82±15.24）％]及CD8＋ CD127＋T细胞[（59.23±14.73）％]较治疗前升高（P＜0.05）,但仍未能达到健康对照组水平（P＜0.05）.结论 ART可以使HIV感染者血浆IL-7水平及T淋巴细胞上CD127表达较治疗前恢复,但仍不能达到健康人群水平.

Objective To explore the effect of anti-retroviral therapy on interleukin（IL）-7/IL-7R in human immunodeficiency virus（HIV） infected patients in China. Methods Cases were divided into 2 groups： HIV-infected group （35 cases）, and control group （30 cases）. IL-7 in serum, IL-7R（CD127）expression in CD4＋T cells, and CD4 ＋T cells count were detecfed and compared between two groups before and after treatment for 1 year. Results IL-7 level in theserum of HIV infected group before treatment [ （8. 98±3.77）pg/ml] was significantly higher than that in control group [ 13.84 ±0. 86）pg/ml] （ P 〈0. 05）. The counts of CD4＋ T cells [ （202. 65 ± 121.54）/ul ], CD4＋ CD127 ＋ T cells [ （60. 25 ± 11.75 ） % ], and CD8 ＋ CD127＋ T cells [ （46. 27 ±12. 10） % ] in HIV-infected group were significantly lower than those in control group [ （766. 99± 103.21 ）/L, （76. 89 ± 20.01 ）%, （ 81.27 ±12. 35 ） %] （ P 〈 0. 05 ）. After anti-retroviral therapy （ART）, IL-7 level in the serum of HIV-infeeted group [ （5.55 ± 1.35 ）pg/ml ] was decreased, and CD4＋T ceUs[ （450. 58 ± 15）/ul], CD4 ＋ CD127 ＋T cells [ （69. 82± 15.24）% ], and [ CD8＋ CD127＋ T（59. 23 ± 14.73 ）% ] cells was increased in HIV-infected group, with a significant difference between two groups （ P 〈 0.05 ）. Conclusions ART could improve the IL-7 level in the serum and IL-7R（CD127） expression in CD4＋ T cells of HIV-infected patients. However, they still cannot become normal level.